Walitza, Susanne and Scherag, Andre and Renner, Tobias J. and Hinney, Anke and Remschmidt, Helmut and Herpertz-Dahlmann, Beate and Schulz, Eberhard and Schafer, Helmut and Lange, Klaus W. and Wewetzer, Christoph and Gerlach, Manfred (2008) Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. JOURNAL OF NEURAL TRANSMISSION, 115 (7). pp. 1071-1078. ISSN 0300-9564,
Full text not available from this repository. (Request a copy)Abstract
The dopaminergic system has been shown to be involved in the aetiology of obsessive-compulsive disorder (OCD). Family studies suggest a higher genetic loading in patients with early onset OCD. Our investigation is the first family-based association study concerning polymorphisms in genes of the dopaminergic system in early onset OCD. We studied polymorphisms within the dopamine-4 receptor gene (DRD4), the dopamine transporter gene (DAT1) and the catecholamine-O-methyltransferase gene (COMT). Associations of alleles of DRD4 and COMT with OCD have previously been reported in adults, while a trend towards an association was found for DAT1 alleles. In our study we observed transmission disequilibrium for the 48-bp repeat polymorphism of the DRD4 gene using the ETDT (P = 0.047) in 69 trios comprising patients with early onset OCD and both of their parents. Post hoc TDT analysis of the DRD4 showed reduced transmission of the 4-repeat allele and a slightly increased transmission rate for the 7- and the 2-repeat allele. No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CATECHOL-O-METHYLTRANSFERASE; 5-HT2A PROMOTER POLYMORPHISM; D4 RECEPTOR GENE; ASSOCIATION ANALYSIS; TRANSPORTER DENSITY; CANDIDATE GENES; DRD4 GENE; COMT; ADOLESCENTS; VARIANTS; genetics; family-based association study; obsessive-compulsive disorder; OCD; psychiatric disorders; dopaminergic system |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Oct 2020 11:06 |
| Last Modified: | 28 Oct 2020 11:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30688 |
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