Denzel, Andrea and Maus, Ulrich A. and Gomez, Manuel Rodriguez and Moll, Cordula and Niedermeier, Marianne and Winter, Christine and Maus, Regina and Hollingshead, Susan and Briles, David E. and Kunz-Schughart, Leoni A. and Talke, Yvonne and Mack, Matthias (2008) Basophils enhance immunological memory responses. NATURE IMMUNOLOGY, 9 (7). pp. 733-742. ISSN 1529-2908,
Full text not available from this repository. (Request a copy)Abstract
The cellular basis of immunological memory remains a controversial issue. Here we show that basophils bound large amounts of intact antigens on their surface and were the main source of interleukins 6 and 4 in the spleen and bone marrow after restimulation with a soluble antigen. Depletion of basophils resulted in a much lower humoral memory response and greater susceptibility of immunized mice to sepsis induced by Streptococcus pneumoniae. Adoptive transfer of antigen-reactive basophils significantly increased specific antibody production, and activated basophils, together with CD4(+) T cells, profoundly enhanced B cell proliferation and immunoglobulin production. These basophil-dependent effects on B cells required interleukins 6 and 4 and increased the capacity of CD4(+) T cells to provide B cell help. Thus, basophils are important contributors to humoral memory immune responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAST-CELL DEGRANULATION; ANTIGEN-CAPTURING CELLS; SURFACE PROTEIN-A; FC-GAMMA RIII; NON-T CELLS; BONE-MARROW; B-CELLS; STREPTOCOCCUS-PNEUMONIAE; ALLERGIC INFLAMMATION; PRODUCE INTERLEUKIN-4; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Oct 2020 05:39 |
| Last Modified: | 29 Oct 2020 05:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30700 |
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