Mueller-Richter, Urs D. A. and Dowejko, Albert and Zhou, Weiqi and Reichert, Torsten E. and Driemel, Oliver (2008) Different expression of MAGE-A-antigens in foetal and adult keratinocyte cell lines. ORAL ONCOLOGY, 44 (7). pp. 628-633. ISSN 1368-8375,
Full text not available from this repository. (Request a copy)Abstract
MAGE-A-antigens are an immunologic marker for many cancers. The goal of this study was to compare the expression profiles of MAGE-A2, -A3, -A4, -A6 and -A10 in foetal and adult keratinocytes with an oral squamous cell carcinoma (OSCC) cell line. Expression of MAGE-A2, -A3, -A4, -A6 and -A10-antigens were detected with PCR in foetal and adult keratinocyte cell lines and in an OSCC cell line (pT4N1M0). Quantitative expression of the single MAGE-A-antigens was measured with rtq-PCR. The results were compared to the reference value of the adult keratinocyte cell line. MAGE-A-antigens were detected in all cell tines. Expression profiles of adult and foetal keratinocyte cell lines differed significantly. Expression profiles of foetal and carcinoma cell lines differed significantly also. MAGE-A-antigens were detected in foetal keratinocyte cell line and oral squarrous cell carcinoma cell line but differ in their expression profiles. Up to now MAGE-A-antigens were not detected in foetal keratinocytes. Their rote is still unknown. (C) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECK SQUAMOUS CARCINOMA; CANCER-TESTIS ANTIGENS; CANCER/TESTIS ANTIGENS; ONCOPROTEIN GANKYRIN; GENES; HEAD; P53; IMMUNOTHERAPY; IDENTIFICATION; TOLERANCE; MAGE-A-antigens; cancer/testis-antigens; oral squamous cell carcinoma; keratinocytes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Oct 2020 05:57 |
| Last Modified: | 29 Oct 2020 05:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30703 |
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