Verstrepen, Babs E. and Bins, Adriaan D. and Rollier, Christine S. and Mooij, Petra and Koopman, Gerrit and Sheppard, Neil C. and Sattentau, Quentin and Wagner, Ralf and Wolf, Hans and Schumacher, Ton N. M. and Heeney, Jonathan L. and Haanen, John B. A. G. (2008) Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates. VACCINE, 26 (26). pp. 3346-3351. ISSN 0264-410X,
Full text not available from this repository. (Request a copy)Abstract
The new intradermal DNA delivery technique, termed DNA tattooing might overcome the discrepancy between the encouraging immunogenicity results obtained with DNA vaccines in murine studies and the poor results obtained in non-human primates and humans, the so called "simian barrier". Here, we demonstrate a 10- to 100-fold increase in the magnitude of vaccine specific T-cell responses in peripheral blood from DNA tattooed rhesus macaques, as compared to T-cell responses in animals immunized via intramuscular (IM) route. A marked increase in the magnitude of the antigen specific T-cell responses as well as an increase in the number of animals responding to the immunogens was observed. These findings in non-human primates suggest that similar results may be observed in humans. Clinical trials are planned to validate tattooing as an optimal method of DNA vaccine delivery in humans. (C) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNE-RESPONSES; LANGERHANS CELLS; VACCINE; VIRUS; IMMUNOGENICITY; EXPRESSION; PROTECTION; CHALLENGE; EFFICACY; DELIVERY; DNA; HIV; Primate |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Oct 2020 06:30 |
| Last Modified: | 29 Oct 2020 06:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30725 |
Actions (login required)
 |
View Item |
