Templeton, Amanda and Nguyen, Gabrielle and Ash, John D. and Straub, Rainer H. and Carr, Daniel J. J. (2008) Chemical sympathectomy increases susceptibility to ocular herpes simplex virus type 1 infection. JOURNAL OF NEUROIMMUNOLOGY, 197 (1). pp. 37-46. ISSN 0165-5728,
Full text not available from this repository. (Request a copy)Abstract
The cornea is one of the most highly innervated tissues in the mammalian host. We hypothesized changes to cornea innervation through chemical sympathectomy would significantly alter the host response to the neurotropic viral pathogen, herpes simplex virus type 1 (HSV-1) following ocular infection. Mice treated with 6-hydroxydopamine hydrobromide displayed reduced tyrosine hydroxylase-positive fibers residing in the cornea. Sympathectomized mice were also found to show a transient rise in virus recovered in infected tissues and succumbed to infection in greater numbers. Whereas there were no differences in infiltrating leukocyte populations including HSV-1-specific cytotoxic T lymphocytes in the infected tissue, an increase in Substance P and a decrease in IFN-gamma levels in the trigeminal ganglion but not brain stern of sympathectomized mice were noted. Sympathectomized mice treated with the neurokinin-1 receptor antagonist L703,606 had delayed mortality implicating the involvement of substance P in HSV-1-mediated death. (C) 2008 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUBSTANCE-P; NERVOUS-SYSTEM; LYMPHOCYTE-ACTIVATION; RHEUMATOID-ARTHRITIS; TRIGEMINAL GANGLION; IMMUNE INTERACTIONS; T-CELLS; MICE; CORNEA; NEURONS; herpes simplex virus 1; 6-hydroxydopamine; substance P |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Oct 2020 08:21 |
| Last Modified: | 29 Oct 2020 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30733 |
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