Dickinson, A. M. and Holler, E. (2008) Polymorphisms of cytokine and innate immunity genes and GVHD. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 21 (2). pp. 149-164. ISSN 1521-6926
Full text not available from this repository. (Request a copy)Abstract
In the last 10 years, non-HLA genotypes have been investigated for their potential roles in the occurrence and severity of graft-versus-host disease (GVHD) as well as for their contribution to overall transplant-related mortality, infectious episodes, and overall survival. This chapter will review the latest results of cytokine gene polymorphisms between patient and donor which may cause the production of high or low levels of cytokines during the three-stage process of the GVHD 'cytokine storm'. More recent investigations into innate immunity and the interaction with subsequent downstream cytokine production and ultimate tissue damage are discussed. The potential of these non-HLA genetics to aid in predicting GVHD and post-transplant survival and the relevance of this information to the clinic are reviewed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; INTERLEUKIN-1 RECEPTOR ANTAGONIST; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; DEPENDENT DIABETES-MELLITUS; DONOR T-CELLS; TNF-ALPHA; INTERFERON-GAMMA; haematopoietic stem-cell transplantation; non-HLA genetics; graft-versus-host disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Jan 2021 16:38 |
| Last Modified: | 14 Jan 2021 16:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30765 |
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