Gleich, Otto and Pina, Ana Luisa (2008) Protein expression of pigment-epithelium-derived factor in rat cochlea. CELL AND TISSUE RESEARCH, 332 (3). pp. 565-571. ISSN 0302-766X,
Full text not available from this repository. (Request a copy)Abstract
Pigment-epithelium-derived factor (PEDF) is a 50-kDa glycoprotein with well-recognised expression in various mammalian organs showing diverse (e.g. antiangiogenic and neuroprotective) activities. However, at present, no information is available regarding the potential function of this cytokine in the inner ear. As a first approach to investigating whether PEDF is involved in cochlear function, we have explored its protein expression in the rat cochlea by immunocytochemistry. Our results show that PEDF expression in the cochlea is most prominent in the basilar membrane below the organ of Corti, in the lateral wall (especially in the stria vascularis), in ganglion neurons, and in the endothelia of blood vessels. Our findings on its distribution in the cochlea suggest that PEDF in the basilar membrane prevents blood vessel formation that would disturb cochlear micromechanics and would interfere with the mechano-electrical transduction in the organ of Corti. In cochlear ganglion neurons, PEDF might serve a neuroprotective function possibly protecting these neurons from excessive glutamate released by the inner hair cells. Our data constitute the first report on the morphological protein distribution of this multifunctional molecule in the rat cochlea and suggest its role in important functions of the internal ear.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR PEDF; INNER-EAR; CELLS; EXCITOTOXICITY; NEURONS; REPAIR; NOISE; VEGF; PEDF; organ of Corti; basilar membrane; cochlear ganglion neurons; glutamate; anti-angiogenic factors; organ development; rat |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2020 05:25 |
| Last Modified: | 02 Nov 2020 05:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30772 |
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