Blana, Andreas and Murat, Francois J. and Walter, Bernhard and Thuroff, Stefan and Wieland, Wolf F. and Chaussy, Christian and Gelet, Albert (2008) First analysis of the long-term results with transrectal HIFU in patients with localised prostate cancer. EUROPEAN UROLOGY, 53 (6). pp. 1194-1203. ISSN 0302-2838, 1873-7560
Full text not available from this repository. (Request a copy)Abstract
Objective: To evaluate the long-term efficacy of high-intensity focused ultrasound (HIFU) therapy for patients with localised prostate cancer. Material and methods: Patients included in this multicentre analysis had T1-T2 NxM0 prostate cancer, a PSA < 15 ng/ml, and a Gleason score (GS) <= 7, and were treated with prototypes or first-generation Ablatherm (TM) HIFU devices between October 1997 and August 2001. The Phoenix definition of biochemical failure was used (PSA nadir + 2). Treatment failure was defined as: biochemical failure or positive biopsy. Results: A total of 140 patients with a mean (SD) age 69.1 yr (6.6) were included. Mean (SD) follow-up was 6.4 yr (1.1). Control prostate biopsies were negative in 86.4% of patients. Median PSA nadir of 0.16 ng/ml (range, 0.0-9.1) was achieved at a mean (SD) of 4.9 mo (5.2). A PSA nadir <= 0.5 ng/ml was recorded in 68.4% of patients. The actuarial biochemical failure-free survival rates (SR) at 5 and 7 yr were 77% and 69%, respectively. The actuarial disease-free SR at 5 and 7 yr were 66% and 59%, respectively. Conclusions: This study demonstrates the effective long-term cancer control achieved with HIFU in patients with low- or intermediate-risk localised prostate cancer. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTENSITY FOCUSED ULTRASOUND; THERAPY; EXPERIENCE; RADIOTHERAPY; ADENOCARCINOMA; IMPLANTATION; SURVIVAL; FAILURE; MEN; localised prostate cancer; HIFU; long-term outcome; minimally invasive therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2020 05:40 |
| Last Modified: | 02 Nov 2020 05:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30788 |
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