Langgartner, Julia and Vasold, Antje and Glueck, Thomas and Reng, Michel and Kees, Frieder (2008) Pharmacokinetics of meropenem during intermittent and continuous intravenous application in patients treated by continuous renal replacement therapy. INTENSIVE CARE MEDICINE, 34 (6). pp. 1091-1096. ISSN 0342-4642,
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Objective: The clinical effect of beta-lactam antibiotics depends on the time of drug concentration above the minimal inhibitory concentration ( MIC) for a susceptible bacterium. Continuous infusion ( CI) of ss-lactams such as meropenem may therefore be a more rational approach than intermittent bolus injections ( IB). The aim of this study was to test whether CI of meropenem achieves effective drug concentrations comparable to IB in patients treated by continuous renal replacement therapy ( CRRT). Design: Prospective, randomised cross-over study. Setting: Twelve-bed medical intensive care unit ( ICU). Patients and interventions: Six ICU patients were randomised to receive either meropenem 1 g IB every 12 h or a 0.5 g i.v. loading dose followed by 2g i.v. CI over 24h. After 2 days, regimens were crossed over. Meropenem pharmacokinetics were determined on days 2 and 4. Measurements and results: Peak serum concentration [ median ( 25% and 75% quartiles)] after short infusion of 1 g meropenem were 62.8 ( 51.4; 85.0) mg/l, trough levels at 12 h were 8.1 (4.5; 18.7) mg/l, and serum half-life was 5.3 (5.1; 7.0) h. Steady-state concentrations during CI were 18.6 (13.3; 24.5) mg/l. The AUCs during either treatment were comparable and determined as 233 ( 202; 254) mg/l*h ( IB) and 227 ( 182; 283) mg/l*h ( CI), respectively. Four hours after IB, drug concentrations dropped below CI steady-state concentrations. Conclusion: Appropriate antibacterial concentrations of meropenem in patients with CRRT are easily achievable with CI. CI may be an effective alternative dosing regimen to IB. A prospective comparison of the clinical efficacy of the two dosage regimens is warranted.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTINUOUS VENOVENOUS HEMOFILTRATION; CRITICALLY-ILL PATIENTS; CONTINUOUS-INFUSION; CYSTIC-FIBROSIS; BETA-LACTAMS; HEMODIAFILTRATION; STABILITY; FAILURE; DOSAGE; SERUM; meropenem; beta-lactam antibiotics; continuous infusion; pharmacokinetics; CVVHD; renal replacement therapy; pharmacodynamics |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Oct 2020 12:54 |
| Last Modified: | 29 Oct 2020 12:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30798 |
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