Springer, Ingo N. G. and Niehoff, Peter and Acil, Yahya and Marget, Matthias and Lange, Arne and Warnke, Patrick H. and Pielenz, Helge and Roldan, J. Camilo and Wiltfang, Joerg (2008) BMP-2 and bFGF in an irradiated bone model. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 36 (4). pp. 210-217. ISSN 1010-5182, 1878-4119
Full text not available from this repository. (Request a copy)Abstract
Introduction: Basic fibroblast growth factor (bFGF) is considered to enhance angiogenesis and to support bone formation in the presence of vital bone cells. Bone morphogenetic protein-2 (rhBMP-2) is known to induce bone formation. The aim of this study was to analyze the effect of bFGF and rhBMP-2 in the irradiated mandible. Material and methods: The right mandibles of 24 rats were irradiated with a single dose of 20 Gy at a high-dose-rate (HDR) after loading machine (bio effective equivalent dose to ca. 45 X 2 Gy). After 12 weeks 100 mu g rhBMP-2 (n = 6 animals, group 1), 100 mu g bFGF (n = 6 animals, group 2) and 100 mu g rhBMP-2 plus 100 mu g bFGF (n = 6 animals, group 3) were injected along the right mandible (left mandible: no irradiation, no growth factor). Another 6 animals (group 4) remained untreated after the irradiation. After another 7 weeks the specimens were examined by non-decalcified histology. Results: Bone apposition of the experimental versus control sides was not statistically significantly different when one of the growth factors was applied alone (rhBMP-2:p = 0.917; bFGF:p = 0.345). Average bone apposition was significantly decreased on the experimental sides of group 3 (rhBMP-2 + bFGF: p = 0.046) and group 4 (p = 0.008). Average bone densities were unaffected in all settings (for all p > 0.1). Conclusions: The application of bFGF and the application of rhBMP-2 alone did result in predictable bone generation in the irradiated mandible with the bone apposition being equal to that of the non-irradiated side. The application of both growth factors together or none at all after irradiation results in significantly reduced bone apposition. (C) 2007 European Association for Cranio-Maxillofacial Surgery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MARROW STROMAL CELLS; GROWTH-FACTOR BFGF; MORPHOGENETIC PROTEIN-2; MANDIBULAR RECONSTRUCTION; CALVARIAL DEFECTS; HYPERBARIC-OXYGEN; INFANT MODEL; FOLLOW-UP; NOGGIN; TISSUE; bone-regeneration; osteoradionekrosis; BMP-2; bFGF; craniectomy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2020 06:58 |
| Last Modified: | 02 Nov 2020 06:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30812 |
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