Fejer, Gyoergy and Koroknai, Anita and Banati, Ferenc and Gyoery, Ildiko and Salamon, Daniel and Wolf, Hans and Niller, Hans Helmut and Minarovits, Janos (2008) Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus. JOURNAL OF GENERAL VIROLOGY, 89. pp. 1364-1370. ISSN 0022-1317, 1465-2099
Full text not available from this repository. (Request a copy)Abstract
Transcripts for the Epstein-Barr virus (EBV)-encoded nuclear antigens are initiated at the alternative promoters Wp, Cp and Qp. Although the host cell-dependent activity of Cp is regulated by DNA methylation, Qp is unmethylated independently of its activity. Because histone modifications affect the chromatin structure, we compared the levels of diacetylated histone H3, tetraacetylated histone H4 and histone H3 dimethylated on lysine 4 (H3K4me2) at Cp and Qp, in well characterized cell lines representing the major EBV latency types. We found an activity-dependent histone code: acetylated histones marked active Cp, whereas active Qp was selectively enriched both in acetylated histones and H3K4me2. We concluded that active (but not silent) Cp and Qp are located to 'acetylation islands' in latent, episomal EBV genomes, similar to the active chromatin domains of the human genome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL LINE C666-1; HISTONE DEACETYLASE; DNA METHYLATION; NUCLEAR ANTIGEN-2; CONTROL REGION; IN-VIVO; EXPRESSION; CHROMATIN; TRANSCRIPTION; GENES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2020 07:11 |
| Last Modified: | 02 Nov 2020 07:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30814 |
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