Winner, Beate and Rockenstein, Edward and Lie, D. Chichung and Aigner, Robert and Mante, Michael and Bogdahn, Ulrich and Couillard-Despres, Sebastien and Masliah, Eliezer and Winkler, Juergen (2008) Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. NEUROBIOLOGY OF AGING, 29 (6). pp. 913-925. ISSN 0197-4580,
Full text not available from this repository. (Request a copy)Abstract
In Parkinson disease, wild-type alpha-synuclein accumulates during aging, whereas alpha-synuclein mutations lead to an early onset and accelerated course of the disease. The generation of new neurons is decreased in regions of neurogenesis in adult mice overexpressing wild-type human alpha-synuclein. We examined the subventricular zone/olfactory bulb neurogenesis in aged mice expressing either wild-type human or A53T mutant alpha-synuclein. Aging wild-type and mutant alpha-synuclein-expressing animals generated significantly fewer new neurons than their non-transgenic littermates. This decreased neurogenesis was caused by a reduction in cell proliferation within the subventricular zone of mutant alpha-synuclein mice. In contrast, no difference was detected in mice overexpressing the wild-type allele. Also, more TUNEL-positive profiles were detected in the subventricular zone, following mutant alpha-synuclein expression and in the olfactory bulb, following wild-type and mutant alpha-synuclein expression. The impaired neurogenesis in the olfactory bulb of different transgenic alpha-synuclein mice during aging highlights the need to further explore the interplay between olfactory dysfunction and neurogenesis in Parkinson disease. (C) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADULT OLFACTORY-BULB; EPIDERMAL-GROWTH-FACTOR; LEWY-BODY-DISEASE; A-BETA COMPONENT; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; CELL-DEATH; SUBVENTRICULAR ZONE; GAMMA-SYNUCLEIN; RAT HIPPOCAMPUS; cell death; neural stem/progenitor cells; neurogenesis; olfactory bulb; Parkinson's disease; synucleinopathy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Oct 2020 13:20 |
| Last Modified: | 29 Oct 2020 13:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30844 |
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