Schwarz, Stephan and Ettl, Tobias and Kleinsasser, Norbert and Hartmann, Arndt and Reichert, Torsten-Eugen and Driemel, Oliver (2008) Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors. ORAL ONCOLOGY, 44 (6). pp. 563-570. ISSN 1368-8375,
Full text not available from this repository. (Request a copy)Abstract
Maspin, a 42 kDa protein, belongs to the serine protease inhibitor (serpin) family and is suggested to have inhibitory effects on tumor-induced angiogenesis, tumor cell motility, invasion and metastasis and influences prognosis of tumor patients. The aim of the study was to analyze Maspin expression in salivary gland cancer as well as its prognostic impact on survival. in comparison to clinical parameters. Immunohistochemical. staining was carried out in 73 cases of salivary gland malignancies. High proportions of Maspin expression were observed in adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas ex pleomorphic adenoma, tow proportions were seen in salivary duct carcinomas. Acinic cell carcinomas did not show any Maspin expression. Analysis of the prognostic impact of Maspin expression was restricted to salivary gland carcinoma types of intermediate malignancy grade (adenoid cystic carcinoma, mucoepidermoid carcinoma and carcinoma ex pleomorphic adenoma). For these tumors, univariate analyses revealed that T-stage (p = 0.025), age >= 70 (p = 0.0065), loss of Maspin (p = 0.0016) and presence of residual tumor (p < 0.001) correlated with poor prognosis. In multivariate analysis age >= 70 (p = 0.005) and loss of Maspin (p = 0.036) were significant prognostic factors. Moreover, negative Maspin staining was associated with Lymph node metastasis and residual. tumor. According to these findings, Maspin might be useful as a new prognostic marker in adenoid cystic carcinoma and in salivary gland carcinomas with intermediate grade of malignancy where grading systems are still under debate. (C) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUPPRESSOR GENE MASPIN; ADENOID CYSTIC CARCINOMA; MAMMARY EPITHELIAL-CELLS; EX-PLEOMORPHIC ADENOMA; P53; CANCER; SURVIVAL; BIOMARKERS; FINLAND; PROTEIN; Maspin; salivary gland carcinoma; prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2020 07:25 |
| Last Modified: | 02 Nov 2020 07:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30853 |
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