Weigert, Johanna and Neumeier, Markus and Wanninger, Josef and Wurm, Sylvia and Kopp, Andrea and Schober, Franziska and Filarsky, Michael and Schaeffler, Andreas and Zeitoun, Martina and Aslanidis, Charalampos and Buechler, Christa (2008) Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes. FEBS LETTERS, 582 (12). pp. 1777-1782. ISSN 0014-5793,
Full text not available from this repository. (Request a copy)Abstract
The abundance of the adiponectin receptors, AdipoR1 and AdipoR2, and the effects of the antidiabetic adipokine adiponectin in monocytes of normal-weight and overweight controls and type 2 diabetic patients (T2D) were analyzed. AdipoR1 and AdipoR2 mRNAs were increased in monocytes of obese controls and T2D patients when compared to normal-weight controls, and AdipoR1 mRNA positively correlated to AdipoR2 mRNA, the waist to hip ratio and systemic adiponectin. However, AdipoR1 and AdipoR2 proteins were lower in monocytes of T2D compared to normal-weight donors. Induction of IL-6 and IL-8 by adiponectin, an effect involving p38 MAPK, was also reduced in T2D monocytes. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN MACROPHAGES; GENE-EXPRESSION; NUCLEAR RECEPTORS; FAMILY; CELLS; SENSITIVITY; CYTOKINES; AGONISTS; PATHWAY; DISEASE; adiponectin; monocyte; type 2 diabetes; obesity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2020 13:28 |
| Last Modified: | 02 Nov 2020 13:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30881 |
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