Chen, Xin and Subleski, Jeffrey J. and Kopf, Heather and Howard, O. M. Zack and Maennel, Daniela N. and Oppenheim, Joost J. (2008) Expression of TNFR2 defines a maximally suppressive subset of mouse CD4(+)CD25(+)FoxP3(+) T regulatory cells: Applicability to tumor-infiltrating T regulatory cells. JOURNAL OF IMMUNOLOGY, 180 (10). pp. 6467-6471. ISSN 0022-1767,
Full text not available from this repository. (Request a copy)Abstract
TNFR2 is predominantly expressed by a subset of human and mouse CD4(+)CD25A(+)FoxP3(+) T regulatory cells (Tregs). In this study, we characterized the phenotype and function of TNFR2(+) Tregs in peripheral lymphoid tissues Of normal and tumor-bearing C57BL/6 mice. We found that TNFR2 was expressed on 30-40% of the Tregs of the peripheral activated/memory subset that were most highly suppressive. In contrast, TNFR2(-) Tregs exhibited the phenotype of naive cells and only bad minimal suppressive activity. Although not typically considered to be Tregs, CD4(+) CD25(-) TNFR2(+) cells nevertheless possessed moderate suppressive activity. Strikingly, the suppressive activity of TNFR2(+) Tregs was considerably more potent than that of reportedly highly suppressive CD103(+) Tregs. In the Lewis lung carcinoma model, more highly suppressive TNFR2(+) Tregs accumulated intratumorally than in the periphery. Thus, TNFR2 identifies a unique subset of mouse Tregs with an activated/memory phenotype and maximal suppressive activity that may account for tumor-infiltrating lymphocyte-mediated immune evasion by tumors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; THERAPY; CD25(+); |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Nov 2020 06:00 |
| Last Modified: | 03 Nov 2020 06:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30900 |
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