Stoecklein, Nikolas H. and Hosch, Stefan B. and Bezler, Martin and Stern, Franziska and Hartmann, Claudia H. and Vay, Christian and Siegmund, Annika and Scheunemann, Peter and Schurr, Paulus and Knoefel, Wolfram T. and Verde, Pablo E. and Reichelt, Uta and Erbersdobler, Andreas and Grau, Roger and Ullrich, Axel and Izbicki, Jakob R. and Klein, Christoph A. (2008) Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. CANCER CELL, 13 (5). pp. 441-453. ISSN 1535-6108,
Full text not available from this repository. (Request a copy)Abstract
The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To address this problem, we studied the precursor cells of metastases directly for the identification of prognostic and therapeutic markers and prospectively analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients. Whole-genome screening revealed that primary tumors and lymphatically and hernatogenously disseminated cancer cells diverged for most genetic aberrations. However, we identified chromosome 17q12-21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites. Survival analysis demonstrated that HER2 gain in a single disseminated tumor cell but not in primary tumors conferred high risk for early death.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CYTOKERATIN-POSITIVE CELLS; DISSEMINATED TUMOR-CELLS; BREAST-CANCER; BONE-MARROW; LYMPH-NODES; MULTIVARIATE-ANALYSIS; SQUAMOUS CANCER; LUNG-CANCER; COPY NUMBER; AMPLIFICATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Nov 2020 07:47 |
| Last Modified: | 03 Nov 2020 07:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30925 |
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