Hundsberger, Harald and Verin, Alexander and Wiesner, Christoph and Pflueger, Maren and Dulebo, Alexander and Schuett, Wolfgang and Lasters, Ignace and Maennel, Daniela N. and Wendel, Albrecht and Lucas, Rudolf (2008) TNF: a moonlighting protein at the interface between cancer and infection. FRONTIERS IN BIOSCIENCE-LANDMARK, 13. pp. 5374-5386. ISSN 1093-9946, 1093-4715
Full text not available from this repository. (Request a copy)Abstract
The remarkable ability of TNF, especially in combination with Interferon-gamma or melphalan, to inhibit the growth of malignant tumor cells is so far unmatched. Unfortunately, its high systemic toxicity and hepatotoxicity prevent its systemic use in cancer patients. An elegant manner to circumvent this problem is the isolated limb and liver perfusion for the treatment of melanoma, soft tissue sarcoma and liver tumors, respectively, although the latter method can lead to a reversible hepatotoxicity. In order to allow also the treatment of other cancers with TNF, new strategies have to be developed that aim at sensitizing tumor cells to TNF and at reducing its systemic and liver toxicity, without losing its antitumor efficiency. Moreover, the lectin-like domain of TNF, which is spatially distinct from the receptor binding sites, could be useful in reducing cancer treatment-related pulmonary edema formation. This review will discuss some recent developments in these areas, which can lead to a renewed interest in TNF for the systemic treatment of cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; MICROVASCULAR ENDOTHELIAL-CELLS; EXPERIMENTAL CEREBRAL MALARIA; ACTIVATING POLYPEPTIDE-II; ISOLATED LIMB PERFUSION; ALPHA-DEPENDENT MECHANISM; ALVEOLAR LIQUID CLEARANCE; MEMBRANE-BOUND TNF; FACTOR RECEPTOR; tumor necrosis factor; ATP; hepatotoxicity; lectin-like domain; edema; TNF receptor 2; review |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Jan 2021 11:49 |
| Last Modified: | 13 Jan 2021 11:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30939 |
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