Noeth, Julica and Frankowski, Kevin J. and Neuenswander, Benjamin and Aube, Jeffrey and Reiser, Oliver (2008) Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence. JOURNAL OF COMBINATORIAL CHEMISTRY, 10 (3). pp. 456-459. ISSN 1520-4766,
Full text not available from this repository. (Request a copy)Abstract
A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | C-H INSERTION; PROTEASE INHIBITORS; CONJUGATE ADDITION; ALDOL REACTIONS; HIV PROTEASE; ONE-POT; MALEIMIDES; ANALOGS; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Nov 2020 10:06 |
| Last Modified: | 03 Nov 2020 10:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30963 |
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