Haen, E. and Greiner, C. and Bader, W. and Wittmann, M. (2008) Expanding therapeutic reference ranges using dose-related reference ranges. NERVENARZT, 79 (5). pp. 558-566. ISSN 0028-2804
Full text not available from this repository. (Request a copy)Abstract
Evidence-based therapeutic drug monitoring (TDM), which may be successfully employed to guide drug therapy in clinical routine, supplies all the information from laboratory determination of a drug concentration in a patient's blood specimen. This value is interpreted first of all in relation to a therapeutic reference range that must be established according to the same rules that are generally accepted for clinical studies aimed to license a new drug. The drug concentration may be furthermore interpreted in reference to a dose-related reference range. Thereby a signal is created to alert for individual abnormalities such as drug/drug interactions, gene polymorphisms that give rise to slow/rapid metabolizers, altered function of the excretion organs liver and kidneys by age and/or disease, compliance problems, a missing pharmacokinetic steady state, and even signal overlay in the laboratory analysis. We return all information available and clinical pharmacological comments to physicians who send specimens to our laboratory.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRIMIPRAMINE PHARMACOKINETICS; HEALTHY-VOLUNTEERS; PSYCHOTIC-PATIENTS; SINGLE; TOLERABILITY; CLOZAPINE; PHARMACODYNAMICS; BIOAVAILABILITY; SCHIZOPHRENIA; OXCARBAZEPINE; therapeutic drug monitoring; therapeutic reference range; dose-related reference range |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Jan 2021 11:46 |
| Last Modified: | 13 Jan 2021 11:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30977 |
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