Slattery, David A. and Hillerer, Katharina M. (2016) The maternal brain under stress: Consequences for adaptive peripartum plasticity and its potential functional implications. FRONTIERS IN NEUROENDOCRINOLOGY, 41. pp. 114-128. ISSN 0091-3022, 1095-6808
Full text not available from this repository.Abstract
The peripartum period represents a time during which all mammalian species undergo substantial physiological and behavioural changes, which prepare the female for the demands of motherhood. In addition to behavioural and physiological alterations, numerous brain regions, such as the medial prefrontal cortex, olfactory bulb, medial amygdala and hippocampus are subject to substantial peripartum-associated neuronal, dendritic and synaptic plasticity. These changes, which are temporally- and spatially-distinct, are strongly influenced by gonadal and adrenal hormones, such as estrogen and cortisol/corticosterone, which undergo dramatic fluctuations across this period. In this review, we describe our current knowledge regarding these plasticity changes and describe how stress affects such normal adaptations. Finally, we discuss the mechanisms potentially underlying these neuronal, dendritic and synaptic changes and their functional relevance for the mother and her offspring. (C) 2016 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENDRITIC SPINE DENSITY; HIPPOCAMPAL CELL-PROLIFERATION; MEDIAL PREFRONTAL CORTEX; PITUITARY-ADRENAL AXIS; ADULT FEMALE RATS; AFFECTS SPATIAL REFERENCE; CHRONIC RESTRAINT STRESS; DEPRESSIVE-LIKE BEHAVIOR; ESTROGEN-RECEPTOR-ALPHA; CA3 PYRAMIDAL NEURONS; Neurogenesis; Stress; Corticosterone; Estrogen |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 01 Sep 2020 06:13 |
| Last Modified: | 01 Sep 2020 06:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3105 |
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