Maity, Prantik and Koenig, Burkhard (2008) Synthesis and structure of 1,4-dipiperazino benzenes: Chiral terphenyl-type peptide helix mimetics. ORGANIC LETTERS, 10 (7). pp. 1473-1476. ISSN 1523-7060, 1523-7052
Full text not available from this repository. (Request a copy)Abstract
The terphenyl structure has been proven to be an ideal scaffold mimicking side-chain functionalities of peptidic alpha-helices. The synthesis of 1,4-dipiperazino benzenes, using stepwise transition metal-catalyzed N-arylation of chiral piperazines to a central benzene core is reported. The structure determination by X-ray crystallography reveals a geometrical arrangement of the hydrophobic side chains resembling the orientation of key i, i + 3, and i + 7 positions in a peptidic alpha-helix or in terphenyl helix mimetics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PALLADIUM-CATALYZED AMINATION; PROTEIN-PROTEIN INTERACTIONS; NITROGEN BOND FORMATION; ALPHA-HELIX; ARYL HALIDES; SECONDARY STRUCTURE; ROOM-TEMPERATURE; AROMATIC AMINATION; COUPLING REACTIONS; AMINES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Nov 2020 10:00 |
| Last Modified: | 04 Nov 2020 10:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31060 |
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