Schmidt, C. and Creutzenberg, M. and Piso, P. and Hobbhahn, J. and Bucher, M. (2008) Peri-operative anaesthetic management of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. ANAESTHESIA, 63 (4). pp. 389-395. ISSN 0003-2409, 1365-2044
Full text not available from this repository. (Request a copy)Abstract
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is a long and complex procedure with significant blood and fluid loss during debulking and important pathophysiological alterations during the HIPEC phase. We performed a retrospective analysis of 78 consecutive patients undergoing cytoreductive surgery with HIPEC at a university hospital. Our data demonstrate large intra-operative fluid turnover, with 51% of patients requiring a blood transfusion. During HIPEC, airway pressure and central venous pressure increased with a lower oxygenation ratio as a result of increased intra-abdominal pressure with the closed abdomen technique. As a consequence of the raised body temperature, heart rate, end tidal carbon dioxide and arterial lactate levels increased with a slight metabolic acidosis. Peri-operative analysis of routine clotting parameters revealed disturbances of the coagulation status. For pain management, 72% of patients received supplementary thoracic epidural analgesia with consequential peri-operative opioid sparing and a reduced duration of postoperative ventilation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOUBLE EPIDURAL CATHETER; POSTOPERATIVE ANALGESIA; PERITONEAL PERFUSION; LAPAROSCOPIC SURGERY; INTRAVENOUS MORPHINE; PNEUMOPERITONEUM; PRESSURE; OXYGENATION; SCOLIOSIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Nov 2020 10:28 |
| Last Modified: | 04 Nov 2020 10:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31064 |
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