Hildebrandt, Gerhard C. and Olkiewicz, Krystyna M. and Corrion, Leigh and Clouthier, Shawn G. and Pierce, Elizabeth M. and Lin, Chen and Cooke, Kenneth R. (2008) A role for TNF receptor type II in leukocyte infiltration into the lung during experimental idiopathic pneumonia syndrome. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14 (4). pp. 385-396. ISSN 1083-8791,
Full text not available from this repository. (Request a copy)Abstract
Idiopathic pneumonia syndrome (IPS) is a frequently fatal complication following allogeneic stem cell transplantation (aflo-SCT). Experimental models have revealed that TNF-alpha contributes to pulmonary vascular endothelial cell (EC) apoptosis, and modulates the infiltration of donor leukocytes into the lung parenchyma. The inflammatory effects of TNF-alpha are mediated by signaling through the type I (TNFRI) or type II (TNFRII) TNF receptors. We investigated the relative contribution of TNFRI and TNFRII to leukocyte infiltration into the lung following allo-SCT by using established murine models. WiId-type (wt) B6 mice or B6 animals deficient in either TNFRI or TNFRII were lethally irradiated and received SCT from allogeneic (LP/J) or syngeneic (136) donors. At week 5 following SCT, the severity of IPS was significantly reduced in TNFRII-/- recipients compared to wt controls, but no effect was observed in TNFRI-/- animals. Bronchoalveolar lavage fluid (BALF) levels of RANTES and pulmonary ICAM-1 expression in TNFRII-/- recipients were also reduced, and correlated with a reduction of CD8(+) cells in the lung. Pulmonary inflammation was also decreased in TNFRII-/- mice using an isolated MHC class I disparate model (bm1 -> B6), and in bm1 wt mice transplanted with B6 TNF-alpha-/- donor cells. Collectively, these data demonstrate a role for TNF-alpha signaling through TNFRII in leukocyte infiltration into the lung following allo-SCT, and suggest that disruption of the TNF-alpha:TNFRII pathway may be an effective tool to prevent or treat IPS. (c) 2008 American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; INTERCELLULAR-ADHESION MOLECULE-1; RESPIRATORY-DISTRESS SYNDROME; SEVERE APLASTIC-ANEMIA; FACTOR-ALPHA; MESSENGER-RNA; INTERSTITIAL PNEUMONITIS; stem cell transplantation; TNF-alpha; cytokines; graft-versus-host disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Nov 2020 10:48 |
| Last Modified: | 04 Nov 2020 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31072 |
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