Dai, Jisen and Jian, Jinlong and Bosland, Maarten and Frenkel, Krystyna and Bernhardt, Gueenther and Huang, Xi (2008) Roles of hormone replacement therapy, and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status. BREAST, 17 (2). pp. 172-179. ISSN 0960-9776,
Full text not available from this repository. (Request a copy)Abstract
Estrogen and iron play critical roles in a female body development and were investigated in the present study in relation to in vitro cell proliferation. Prempro (TM), a hormone replacement therapy drug, and 17 beta-estradiol (E2) were shown to increase cell proliferations in estrogen receptor positive (ER+) cells independent of progesterone receptor (PR) status. For example, increased cell proliferation was observed in ER+/PR+ human breast cancer MCF-7, its matching non-cancerous human breast epithelial MCF-12A, and ER+/PR+ murine mammary cancer MXT+ cells, but not in ER-/PR- MDA(-)MB-231, its matching non-cancerous MCF-10A, and MXT- (ER-/ PR+) cells. By mimicking post-menopausal conditions of high estrogen in local breast tissue and increased iron levels due to cessation of menstrual periods, E2 and iron were shown to exert synergistic effects on proliferation of MCF-7 cells and significantly increased Ki67 and proliferating cell nuclear antigen. Western blotting of E2-treated ER+ but not ER- cells showed that E2 also increased transferrin receptor (TfR). Further studies are needed to assess the mitogenic effects of iron and estrogen in normal post-menopausal breast. (C) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MOUSE MAMMARY-TUMOR; TRANSFERRIN RECEPTOR; POSTMENOPAUSAL WOMEN; SURFACE GLYCOPROTEIN; NEOPLASTIC-CELLS; CANCER; FERRITIN; AROMATASE; STORES; PROGRESSION; iron; estrogen; progesterone; breast cancer; cell proliferation; menopause |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Nov 2020 13:47 |
| Last Modified: | 04 Nov 2020 13:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31076 |
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