Oesterreicher, Christoph H. and Halangk, Juliane and Berg, Thomas and Patsenker, Eleonora and Homann, Nils and Hellerbrand, Claus and Seitz, Helmut K. and Eurich, Dennis and Stickel, Felix (2008) Evaluation of the transforming growth factor beta 1 codon 25 (Arg -> Pro) polymorphism in alcoholic liver disease. CYTOKINE, 42 (1). pp. 18-23. ISSN 1043-4666, 1096-0023
Full text not available from this repository. (Request a copy)Abstract
Introduction: Liver cirrhosis develops only in a minority of heavy drinkers. Genetic factors may account for some variation in the progression of fibrosis in alcoholic liver disease (ALD). Transforming growth factor beta 1 (TGF beta 1) is a key profibrogenic cytokine in fibrosis and its gene contains several polymorphic sites. A single nucleotide polymorphism at codon 25 has been suggested to affect fibrosis progression in patients with chronic hepatitis C virus infection, fatty liver disease, and hereditary hemochromatosis. Its contribution to the progression of ALD has not been investigated sufficiently so far. Patients and methods: One-hundred-and-fifty-one heavy drinkers without apparent ALD, 149 individuals with alcoholic cirrhosis, and 220 alcoholic cirrhotics who underwent liver transplantation (LTX) were genotyped for TGF beta 1 codon 25 variants. Results: Univariate analysis suggested that genotypes Arg/Pro or Pro/Pro are associated with decompensated liver cirrhosis requiring LTX. However, after adjusting for patients' age these genotypes did not confer a significant risk for cirrhosis requiring LTX. Conclusion: TGF beta 1 codon 25 genotypes Arg/Pro or Pro/Pro are not associated with alcoholic liver cirrhosis. Our study emphasizes the need for adequate statistical methods and accurate study design when evaluating the contribution of genetic variants to the course of chronic liver diseases. (c) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSFORMING GROWTH-FACTOR-BETA-1 GENE; MANGANESE SUPEROXIDE-DISMUTASE; HEPATITIS-C INFECTION; NECROSIS-FACTOR-ALPHA; END-POINTS; FIBROSIS; PROGRESSION; ASSOCIATION; CIRRHOSIS; RISK; alcoholic liver disease; cirrhosis; genetic risk; polymorphism; transforming growth factor beta 1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Nov 2020 14:32 |
| Last Modified: | 04 Nov 2020 14:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31081 |
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