Kaess, Bernhard and Fischer, Marcus and Baessler, Andrea and Stark, Klaus and Huber, Fritz and Kremer, Werner and Kalbitzer, Hans Robert and Schunkert, Heribert and Riegger, Guenter and Hengstenberg, Christian (2008) The lipoprotein subfraction profile: heritability and identification of quantitative trait loci. JOURNAL OF LIPID RESEARCH, 49 (4). pp. 715-723. ISSN 0022-2275,
Full text not available from this repository. (Request a copy)Abstract
The HDL and LDL subclass profile is an emerging cardiovascular risk factor. Yet, the biological and genetic mechanisms controlling the lipoprotein subclass distribution are unclear. Therefore, we aimed 1) to determine the heritability of the entire spectrum of LDL and HDL subclass features and 2) to identify gene loci influencing the lipoprotein subfraction pattern. Using NMR spectroscopy, we analyzed the lipoprotein subclass distribution in 1,275 coronary artery disease patients derived from the Regensburg Myocardial Infarction Family Study. We calculated heritabilities, performed a microsatellite genome scan, and calculated linkage. HDL and LDL subclass profiles showed heritabilities ranging from 23% to 67% (all P < 10(-3)) of traits using univariate calculation. After multivariate adjustment, we found heritabilities of 27-48% (all P < 0.05) for HDL and 21-44% for LDL traits. The linkage analysis revealed a significant logarithm of the odds (LOD) score (3.3) for HDL particle concentration on chromosome 18 and a highly suggestive signal for HDL particle size on chromosome 12 (2.9). After multivariate adjustment, we found a significant maximum LOD score of 3.7 for HDL size. Our study is the first to analyze heritability and linkage for the entire spectrum of LDL and HDL subclass features. Our findings may lead to the identification of genes controlling the lipoprotein subclass distribution.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; ISCHEMIC-HEART-DISEASE; MAGNETIC-RESONANCE-SPECTROSCOPY; HEPATIC LIPASE ACTIVITY; ESTER TRANSFER PROTEIN; PLAC-I TRIAL; MYOCARDIAL-INFARCTION; LINKAGE ANALYSIS; PARTICLE-SIZE; linkage analysis; HDL; LDL; subclasses; nmr spectroscopy |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Nov 2020 06:28 |
| Last Modified: | 05 Nov 2020 06:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31117 |
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