Gross, Catharina and Holler, Ernst and Stangl, Stefan and Dickinson, Anne and Pockley, A. Graham and Asea, Alexzander A. and Mallappa, Nagaraj and Multhoff, Gabriele (2008) An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation. LEUKEMIA RESEARCH, 32 (4). pp. 527-534. ISSN 0145-2126,
Full text not available from this repository. (Request a copy)Abstract
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell Surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell trail splantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells. (C) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NATURAL-KILLER-CELLS; HEAT-SHOCK-PROTEIN; BONE-MARROW TRANSPLANTATION; HUMAN TUMOR-CELLS; CYTOLYTIC ACTIVITY; SURFACE EXPRESSION; THERAPY; CANCER; LYMPHOCYTES; hsp70 peptide TKD; HLA-E; NK cells; stem cell transplantation; cytotoxicity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Nov 2020 08:32 |
| Last Modified: | 05 Nov 2020 08:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31133 |
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