Garbe, Claus and Hauschild, Axel and Volkenandt, Matthias and Schadendorf, Dirk and Stolz, Wilhelm and Reinhold, Uwe and Kortmann, Rolf-Dieter and Kettelhack, Christoph and Frerich, Bernhard and Keilholz, Ulrich and Dummer, Reinhard and Sebastian, Guenther and Tilgen, Wolfgang and Schuler, Gerold and Mackensen, Andreas and Kaufmann, Roland (2008) Evidence-based and interdisciplinary consensus-based German guidelines: systemic medical treatment of melanoma in the adjuvant and palliative setting. MELANOMA RESEARCH, 18 (2). pp. 152-160. ISSN 0960-8931, 1473-5636
Full text not available from this repository. (Request a copy)Abstract
Systemic medical treatment of melanoma is administered in the adjuvant and palliative setting. Adjuvant therapy may be considered in patients with primary melanoma with more than 1.5 mm tumor thickness and with regional node metastasis. Presently no indication for systemic adjuvant chemotherapy or for adjuvant therapy with nonspecific immune-stimulatory agents outside controlled studies is seen. Interferon-a is the first substance in the adjuvant therapy of melanoma, which has shown to present a significant advantage to the patients in some prospective randomized studies. Good arguments for using adjuvant interferon-a therapy in high-risk melanoma patients exist. Both high-dose and low-dose interferon-a show promise. The major indications for systemic chemotherapy and chemoimmunotherapy are inoperable recurrent tumors, inoperable regional metastases and distant metastases (stage IV). As treatment in such situations is primarily palliative, the effect of any regimen on the quality of life must be carefully weighed. As a first line treatment, single agent therapy is recommended, as polychemotherapy or biochemotherapy did not show significant advantages for prolongation of survival; hence they are more toxic. An urgent need for development of new treatment modalities is necessary and general principles of experimental immunotherapy are outlined.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METASTATIC MALIGNANT-MELANOMA; PHASE-III TRIAL; HIGH-RISK MELANOMA; SOUTHWEST-ONCOLOGY-GROUP; MULTICENTER RANDOMIZED-TRIAL; INCOMPLETE FREUNDS-ADJUVANT; DENDRITIC CELLS; COMBINATION CHEMOTHERAPY; INTERFERON ALPHA-2A; CUTANEOUS MELANOMA; adjuvant consensus-based evidence; German; guidelines; interdisciplinary; melanoma; systemic medical treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Jan 2021 10:37 |
| Last Modified: | 13 Jan 2021 10:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31135 |
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