Ljubimova, Julia Y. and Fujita, Manabu and Ljubimov, Alexander V. and Torchilin, Vladimir P. and Black, Keith L. and Holler, Eggehard (2008) Poly(malic acid) nanoconjugates containing various antibodies and oligo nucleotides for multitargeting drug delivery. NANOMEDICINE, 3 (2). pp. 247-265. ISSN 1743-5889
Full text not available from this repository. (Request a copy)Abstract
Nanoconjugates are emerging as promising drug-delivery vehicles because of their multimodular structure enabling them to actively target discrete cells, pass through biological barriers and simultaneously carry multiple drugs of various chemical nature. Nanoconjugates have matured from simple devices to multifunctional, biodegradable, nontoxic and nonimmunogenic constructs, capable of delivering synergistically functioning drugs in vivo. This review mainly concerns the Polycefin family of natural-derived polymeric drug-delivery devices as an example. This type of vehicle is built by hierarchic conjugation of functional groups onto the backbone of poly(malic acid), an aliphatic polyester obtained from the microorganism Physarum polycephalum. Particular Polycefin variants target human brain and breast tumors implanted into animals specifically and actively and could be detected easily by noninvasive imaging analysis. Delivery of antisense oligonucleotides to a tumor-specific angiogenic marker using Polycefin resulted in significant inhibition of tumor angiogenesis and increase of animal survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLOOD-BRAIN-BARRIER; PROTEIN-KINASE CK2; EPIDERMAL-GROWTH-FACTOR; TRANSFERRIN RECEPTOR; IN-VIVO; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERS; PHYSARUM-POLYCEPHALUM; MONOCLONAL-ANTIBODY; THERAPEUTIC AGENTS; ANTITUMOR-ACTIVITY; biodegradable; brain cancer; breast cancer; imaging analysis; multiple antibodies; multiple drug delivery; multitargeting; Polycefin; poly(malic acid); tumor angiogenesis |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Alumni or Retired > Prof. Dr. Eggehard Holler |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Jan 2021 12:33 |
| Last Modified: | 14 Jan 2021 12:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31139 |
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