Figueiredo, Ricardo Rodrigues and Langguth, Berthold and de Oliveira, Patricia Mello and de Azevedo, Andreia Aparecida (2008) Tinnitus treatment with memantine. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 138 (4). pp. 492-496. ISSN 0194-5998, 1097-6817
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVE: To evaluate efficacy and safety of memantine in the treatment of tinnitus. STUDY DESIGN: Prospective, randomized, double-blind crossover study. SUBJECTS AND METHODS: A total of 60 patients with tinnitus were randomized into a double-blind, placebo-controlled, prospective crossover study. Patients each received up to 20 mg memantine and placebo for 90 days, separated by a 30-day wash- out period. Treatment effects were assessed by using the Tinnitus Handicap Inventory (THI). A total of 43 patients completed the trial. RESULTS: There was no sianificant improvement of THI score after memantine treatment compared with placebo. A possible tendency for delayed effects of memantine was observed. The incidence of side effects during memantine treatment was 9.4 percent, leading to interruption of treatment in all cases. CONCLUSION: This study does not provide evidence to recommend memantine for the treatment of tinnitus. A possible late effect of the drug should be evaluated in further studies with longer observation periods. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHANTOM LIMB PAIN; RECEPTOR ANTAGONIST; COCHLEA; TRIAL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Nov 2020 08:53 |
| Last Modified: | 05 Nov 2020 08:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31144 |
Actions (login required)
 |
View Item |
