Hildebrandt, Gerhard C. and Choi, Sung W. and Mueller, Gunnar and Olkiewicz, Krystyna M. and Moore, Bethany B. and Cooke, Kenneth R. (2008) The absence of donor-derived IL-13 exacerbates the severity of acute-graft-versus-host disease following allogeneic bone marrow transplantation. PEDIATRIC BLOOD & CANCER, 50 (4). pp. 911-914. ISSN 1545-5009,
Full text not available from this repository. (Request a copy)Abstract
Acute graft versus host disease (aGVHD) after allogeneic bone marrow transplantation (allo-BMT) predominantly involves a Th1-type cytokine response. Interestingly, the Th2-cytokine, Interleukin-13 (IL-13), produced by alloreactive donor T cells in vitro was recently shown to correlate with clinical aGVHD severity. Using an established moose model, we show that the systemic cytokine milieu following allo-BMT with IL-13-/- donors is characterized by decreases in serum Th2 cytokines and an increase in serum TNF alpha, and ultimately correlates with higher aGVHD mortality compared to allogeneic controls. In vitro Studies further demonstrate that both exogenous and T cell-derived IL-13 can regulate TNF alpha production by macrophages following lipopolysaccharide stimulation. Thus, donor-derived IL-13 may have a role in modulating inflammatory cytokine release that is associated with aGVHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; T-CELLS; INTERLEUKIN-13; RECEPTOR; CYTOKINE; RESPONSES; CLONING; ROLES; ALPHA; LUNG; tumor necrosis factor alpha; acute GVHD; T cell; cytokines; IL-13 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Nov 2020 08:58 |
| Last Modified: | 05 Nov 2020 08:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31148 |
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