Ickenstein, G. W. and Valaikiene, J. and Koch, H. and Hau, P. and Erban, P. and Schlachetzki, F. (2008) Ultrasonic contrast agents in transcranial perfusion (TPS) for follow-up of patients with high grade sonography gliomas. ULTRASONICS SONOCHEMISTRY, 15 (4). pp. 510-516. ISSN 1350-4177,
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Purpose: The aim of this study was to evaluate brain perfusion differences in patients with high grade gliomas after partial tumor resection and irradiation/chemotherapy between tumor and non-tumor hemisphere by transcranial perfusion sonography (TPS) employing a contrast burst imaging (CBI) technique. Methods: Six patients with glioblastoma (WHO Grade IV) in the temporoparietal region within the defined axial diencephalic scanning plane were examined by TPS during follow-up. All subjects had an adequate acoustic temporal bone window. Transtemporal insonation on brain tumor and non-tumor hemisphere was performed with a bolus-injection of sulphur hexafluoride-based contrast agent (10 mg IV, 5 mg/ml - SonoVue (R), Bracco, Altana, Switzerland). Recorded images were analysed off-line by Quanticon Software (3D-Echotech, Munich, Germany) and time intensity curve parameters [area under the curve (AUC, dB s), peak intensity (PI, dB), time to peak (TTP, s)] in five regions of interest (ROI) [thalamus anterior, thalamus posterior, nucleus lentiformis, white matter, whole hemisphere] were evaluated. Statistical analyses were performed. Results: Perfusion differences between brain tumor and non-tumor hemispheres were detected with contrast burst imaging (CBI) technique with a significantly greater mean AUC (5343.69 dB s vs. 4625.04 dB s, p < 0.028) and a significantly prolonged TTP (32.72 s vs. 28.91 s, p < 0.046) in the tumor hemisphere. Conclusion: Within our study population, TTP and AUC seem to be the most robust parameters for the evaluation of cerebral perfusion differences assessed by transcranial perfusion sonography with CBI technique. We hypothesize that these results correlate with microvascular changes due to treatment regimens, such as microvessel necrosis after irradiation and chemotherapy. Above that, TPS may be of value for the long-term follow-up of brain tumor therapy concept. (c) 2007 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BRAIN PERFUSION; IMAGING MODES; COLOR DOPPLER; TUMOR PERFUSION; GROWTH-FACTOR; ANGIOGENESIS; RADIATION; TISSUE; QUANTIFICATION; PERMEABILITY; neurosonology ultrasound contrast agent; neurooncology; Transcranial perfusion sonography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Nov 2020 10:15 |
| Last Modified: | 05 Nov 2020 10:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31162 |
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