Kruschinski, Carsten and Skripuletz, Thomas and Bedoui, Sammy and Raber, Kerstin and Straub, Rainer H. and Hoffmann, Torsten and Grote, Karsten and Jacobs, Roland and Stephan, Michael and Pabst, Reinhard and von Hoersten, Stephan (2008) Postnatal life events affect the severity of asthmatic airway inflammation in the adult rat. JOURNAL OF IMMUNOLOGY, 180 (6). pp. 3919-3925. ISSN 0022-1767,
Full text not available from this repository. (Request a copy)Abstract
Genetic and hygienic factors influence susceptibility to asthma. In autoimmune and inflammatory diseases, additional effects of the psychosocial environment have been demonstrated that might also play a role in asthma. In this study, the impact of different early postnatal stressors on an OVA-induced model of asthma was tested in adulthood. Fischer 344 rats were subjected to either repeated handling stimulation (HA), maternal separation (MS), or were left undisturbed in their first 4 wk of life. Behavioral differences were characterized at the age of 4 mo. At 5 mo of age, immunological cellular and serologic changes were investigated and experimental asthma was induced. Results show significantly increased exploratory behavior and reduced anxiety in HA rats compared with MS and controls. Without further behavioral or immunological challenges, HA animals exhibited an increased ex vivo NK cell cytotoxicity but no other obvious immunological differences. After induction of asthma, in contrast, MS animals exhibited proinflammatory effects in leukocyte subset composition including increased eosinophil numbers, whereas levels of IgE and the allergy-specific cytokine IL-13 were reduced compared with HA. There was a most remarkable increase of adrenocorticotropin in HA animals, comparing pre- to postchallenge plasma levels. These data demonstrate for the first time that early postnatal stimulative or adverse experiences exert long-lasting changes of the "neuroendocrinoimmune" interface in adulthood, resulting in either protective or aggravating mechanisms in allergic airway disease. Thus, in addition to genetic and hygienic factors, nongenetically acquired individual differences contribute to the pathobiology of asthma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC IMIPRAMINE TREATMENT; DIPEPTIDYL-PEPTIDASE-IV; SOCIAL-INTERACTION TEST; T-CELLS; PSYCHOSOCIAL STRESS; LEUKOCYTE SUBSETS; LUNG METASTASIS; B-LYMPHOCYTES; RECRUITMENT; MODEL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Nov 2020 11:17 |
| Last Modified: | 05 Nov 2020 11:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31178 |
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