Mahboobi, Siavosh and Eichhorn, Emerich and Winkler, Matthias and Sellmer, Andreas and Moellmann, Ute (2008) Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives - An extended structure-activity relationship study. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 43 (3). pp. 633-656. ISSN 0223-5234,
Full text not available from this repository. (Request a copy)Abstract
Compounds containing 3-bromo-2,5-dihydro-1H-2,5-pyrroledione and indole substructures were found to have antibacterial activity against resistant strains of Staphylococcus aureus and some other Gram positive bacteria. The investigated compounds exhibit minimal inhibition concentrations (MICs) lower than those of common antibiotics like vancomycin or ciprofloxacin. Activity against multiresistant strains suggests a mechanism of action different from common antibiotics. This might be important in circumventing existing resistance mechanisms. Here we report about the antibacterial activity in an extended structure-activity relationship study. (c) 2007 Elsevier Masson SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESISTANCE; INHIBITORS; DESIGN; SAR study; antibacterial compounds; indole derivatives; resistance of staphylococcus aureus |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Nov 2020 10:33 |
| Last Modified: | 09 Nov 2020 10:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31233 |
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