Nickel, Marius K. and Loew, Thomas H. (2008) Treatment of aggression with topiramate in male borderline patients, part II: 18-month follow-up. EUROPEAN PSYCHIATRY, 23 (2). pp. 115-117. ISSN 0924-9338,
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Objective. - We previously tested topiramate, an anticonvulsant, in the treatment of aggression in men with borderline personality disorder (BPD) (Nickel M, Nickel C, Kaplan P, Lahmann C, Muhlbacher M, Tritt K, et al. Treatment of aggression with topiramate in male borderline patients: a double-blind, placebo-controlled study. Biol Psychiatry 2005;57:495-9), and found significant changes on most scales of the state-trait anger expression inventory (STAXI) and significant weight loss eight weeks later. The aim of this trial was to assess topiramate's efficacy in the long-term therapy for aggression in men with BPD. Methods. - This 18-month follow-up observation, in which the previous patients (topiramate group: n = 22; former placebo group: n = 22) were examined bianually, was carried out. Results. - According to the intent-to-treat principle, significant changes on all scales of the STAXI were observed in the subjects treated with topiramate. Additional significant weight loss was observed. All subjects tolerated topiramate relatively well. Conclusions. - Topiramate appears to be an effective, relatively safe agent in the long-term treatment of patients with BPD. Mild, non-transient weight loss can be expected. (C) 2007 Published by Elsevier Masson SAS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DOUBLE-BLIND; PERSONALITY-DISORDER; borderline personality disorder; men's health; aggression; treatment; topiramate; weight loss |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Psychosomatische Medizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Nov 2020 10:41 |
| Last Modified: | 09 Nov 2020 10:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31234 |
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