Hammerstingl, Renate and Huppertz, Alexander and Breuer, Josy and Balzer, Thomas and Blakeborough, Anthony and Carter, Rick and Fuste, Lluis Castells and Heinz-Peer, Gertraud and Judmaier, Werner and Laniado, Michael and Manfredi, Riccardo M. and Mathieu, Didier G. and Mueller, Dieter and Mortele, Koenraad and Reimer, Peter and Reiser, Maximilian F. and Robinson, Philip J. and Shamsi, Kohkan and Strotzer, Michael and Taupitz, Matthias and Tombach, Bernd and Valeri, Gianluca and van Beers, Bernhard E. and Vogl, Thomas J. (2008) Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions. EUROPEAN RADIOLOGY, 18 (3). pp. 457-467. ISSN 0938-7994, 1432-1084
Full text not available from this repository. (Request a copy)Abstract
A multicenter study has been employed to evaluate the diagnostic efficacy of magnetic resonance imaging (MRI) using the new liver-specific contrast agent gadoxetic acid (Gd-EOB-DTPA, Primovist), as opposed to contrast-enhanced biphasic spiral computed tomography (CT), in the diagnosis of focal liver lesions, compared with a standard of reference (SOR). One hundred and sixty-nine patients with hepatic lesions eligible for surgery underwent Gd-EOB-DTPA-enhanced MRI as well as CT within 6 weeks. Pathologic evaluation of the liver specimen combined with intraoperative ultrasound established the SOR. Data sets were evaluated on-site (14 investigators) and off-site (three independent blinded readers). Gd-EOB-DTPA was well tolerated. Three hundred and two lesions were detected in 131 patients valid for analysis by SOR. The frequency of correctly detected lesions was significantly higher on Gd-EOB-DTPA-enhanced MRI compared with CT in the clinical evaluation [10.44%; 95% confidence interval (CI): 4.88, 16.0]. In the blinded reading there was a trend towards Gd-EOB-DTPA-enhanced MRI, not reaching statistical significance (2.14%; 95% CI: -4.32, 8.6). However, the highest rate of correctly detected lesions with a diameter below 1 cm was achieved by Gd-EOB-DTPA-enhanced MRI. Differential diagnosis was superior for Gd-EOB-DTPA-enhanced MRI (82.1%) versus CT (71.0%). A change in surgical therapy was documented in 19 of 131 patients (14.5%) post Gd-EOB-DTPA-enhanced MRI. Gd-EOB-DTPA-enhanced MRI was superior in the diagnosis and therapeutic management of focal liver lesions compared with CT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GD-EOB-DTPA; PHASE HELICAL CT; SUPERPARAMAGNETIC IRON-OXIDE; ARTERIAL PORTOGRAPHY; HEPATIC METASTASES; HEPATOCELLULAR-CARCINOMA; GADOBENATE DIMEGLUMINE; COLORECTAL-CANCER; CONTRAST AGENTS; ULTRASONOGRAPHY; magnetic resonance imaging; computed tomography; focal liver lesions; liver-specific; hepatobiliary; gadoxetic acid-enhanced MRI; therapeutic strategy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Nov 2020 10:43 |
| Last Modified: | 09 Nov 2020 10:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31235 |
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