Schmitz, Gerd and Ecker, Josef (2008) The opposing effects of n-3 and n-6 fatty acids. PROGRESS IN LIPID RESEARCH, 47 (2). pp. 147-155. ISSN 0163-7827
Full text not available from this repository. (Request a copy)Abstract
Polyunsaturated fatty acids (PUFAs) can be classified in n-3 fatty acids and n-6 fatty acids, and in westernized diet the predominant dietary PUFAs are n-6 fatty acids. Both types of fatty acids are precursors of signaling molecules with opposing effects, that modulate membrane microdomain composition, receptor signaling and gene expression. The predominant n-6 fatty acid is arachidonic acid, which is converted to prostaglandins, leukotrienes and other lipoxygenase or cyclooxygenase products. These products are important regulators of cellular functions with inflammatory, atherogenic and prothrombotic effects. Typical n-3 fatty acids are docosahexaenoic acid and eicosapentaenoic acid, which are competitive substrates for the enzymes and products of arachidonic acid metabolism. Docosahexaenoic acid- and eicosapentaenoic acid-derived eicosanoids antagonize the pro-inflammatory effects of n-6 fatty acids. n-3 and n-6 fatty acids are ligands/modulators for the nuclear receptors NF kappa B, PPAR and SREBP-1c, which control various genes of inflammatory signaling and lipid metabolism. n-3 Fatty acids down-regulate inflammatory genes and lipid synthesis, and stimulate fatty acid degradation. In addition, the n-3/n-6 PUFA content of cell and organelle membranes, as well as membrane microdomains strongly influences membrane function and numerous cellular processes such as cell death and survival. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; EPOXYGENASE-DERIVED EICOSANOIDS; BINDING PROTEIN-1 EXPRESSION; ACTIVATED RECEPTOR-GAMMA; RAFT LIPID-COMPOSITION; RETINOID-X-RECEPTOR; DIETARY FISH-OIL; DOCOSAHEXAENOIC-ACID; EICOSAPENTAENOIC ACID; GENE-EXPRESSION; arachidonic acid; docosahexaenoic acid; eicosanoids; eicosapentaenoic acid; gene expression; inflammation; lipid metabolism; n-3; n-6 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 12 Jan 2021 16:58 |
| Last Modified: | 12 Jan 2021 16:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31343 |
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