Langguth, Berthold and Eichhammer, Peter and Spranz, Claus and Landgrebe, Michael and Frick, Ulrich and Sand, Philipp and Hajak, Goeran (2008) Modulation of human motor cortex excitability by quetiapine. PSYCHOPHARMACOLOGY, 196 (4). pp. 623-629. ISSN 0033-3158, 1432-2072
Full text not available from this repository. (Request a copy)Abstract
Rationale Quetiapine is increasingly used for the treatment of patients with psychosis and bipolar disorder. However, the neurobiological mechanisms, which may account for the favourable risk/benefit profile of this drug, are not entirely understood. Objectives Transcranial magnetic stimulation was used to investigate the effects of acute and repeated administration of quetiapine on cortical excitability in healthy volunteers. Materials and methods Within a double-blind, placebo-controlled, randomized cross-over design motor threshold, intracortical inhibition, intracortical facilitation and cortical silent period were studied in 15 healthy volunteers before and after a single dose of placebo and 100 mg quetiapine. Additional measurements were performed after 5 days of daily intake of 100 mg quetiapine. Results We observed a significant prolongation of the cortical silent period after a single dose of quetiapine, whereas the placebo had no effects. After repeated administration, there was a trend towards CSP prolongation, which did not reach significance. However, plasma concentrations at this time point were relatively low, as measurements were performed 15 h after the last drug intake. Other parameters of cortical excitability remained unaffected. Conclusions By lengthening CSP without affecting MT, ICI and ICF, quetiapine demonstrates a unique neurophysiological profile which differs distinctively from brain excitability profiles of typical antipsychotics such as haloperidol. Provided that the CSP prolongation reflects the antipsychotic potential of quetiapine, TMS may be developed as a tool to monitor neurobiological effects of quetiapine treatment in schizophrenic patients and to explore the efficacy of other antipsychotic drugs with a similar mode of action.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; CORTICAL EXCITABILITY; NEGATIVE SYMPTOMS; INHIBITORY DEFICITS; SCHIZOPHRENIA; DISORDER; ANTIPSYCHOTICS; DEPRESSION; PATIENT; BLIND; quetiapine; atypical neuroleptic; neuroplasticity; human motor cortex; excitability; transcranial magnetic stimulation; cortical silent period |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Nov 2020 08:54 |
| Last Modified: | 09 Nov 2020 08:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31345 |
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