Kirby, Giles T. S. and White, Lisa J. and Steck, Roland and Berner, Arne and Bogoevski, Kristofor and Qutachi, Omar and Jones, Brendan and Saifzadeh, Siamak and Hutmacher, DietmarW. and Shakesheff, Kevin M. and Woodruff, Maria A. (2016) Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects. MATERIALS, 9 (4): 259. ISSN 1996-1944,
Full text not available from this repository. (Request a copy)Abstract
This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established preclinical ovine tibial segmental defect measuring 3 cm. After six months, mechanical properties and bone tissue regeneration were assessed. Mineralised bone bridging of the defect was enhanced in growth factor treated groups. The inclusion of VEGF and PDGF (with BMP-2) had no significant effect on the amount of bone regeneration at the six-month time point in comparison to BMP-2 alone. However, regions treated with VEGF and PDGF showed increased vascularity. This study demonstrates an effective method for the controlled delivery of therapeutic growth factors in vivo, using microparticles.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTERIOR CERVICAL DISKECTOMY; PLGA-BASED MICROPARTICLES; IN-VITRO CHARACTERIZATION; MORPHOGENETIC PROTEIN-2; ANGIOGENESIS; RELEASE; VEGF; FUSION; REPAIR; MICROSPHERES; growth factor; scaffold; bone; repair; regeneration; microparticle; segmental defect |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2019 08:48 |
| Last Modified: | 03 Apr 2019 08:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3139 |
Actions (login required)
 |
View Item |
