Hiller, A. and Fischer, C. and Jordanova, A. and Patt, J. T. and Steinbach, J. (2008) Investigations to the synthesis of n.c.a. [F-18]FClO3 as electrophilic fluorinating agent. APPLIED RADIATION AND ISOTOPES, 66 (2). pp. 152-157. ISSN 0969-8043,
Full text not available from this repository. (Request a copy)Abstract
An approach to synthesize the electrophilic fluorinating agent no-carrier-added (n.c.a.) [F-18]perchloryl fluoride ([F-18]FClO3) in superacidic media in the presence of KClO4 or anhydrous perchloric acid starting from [F-18]fluoride was demonstrated in this study. However. the radiochemical yields were low (1-6%) and poorly reproducible. Fluorosulphonic acid proved to be an essential intermediate as revealed by non-radioactive experiments. A key problem in the preparation of [F-18]FClO3 is the assumed kinetic inhibition due to the unfavourable stoichiometric ratio of the ClO4 moiety to [F-18]HSO3F. (C) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERCHLORYL FLUORIDE; CLO3F; fluorine-18; perchloryl fluoride; electrophilic fluorination; no carrier added |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Nov 2020 06:31 |
| Last Modified: | 10 Nov 2020 06:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31390 |
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