Moeius-Winkler, Sven and Schuler, Gerhard C. and Sick, Peter B. (2008) Interventional treatments for stroke prevention in atrial fibrillation with emphasis upon the WATCHMAN device. CURRENT OPINION IN NEUROLOGY, 21 (1). pp. 64-69. ISSN 1350-7540, 1473-6551
Full text not available from this repository. (Request a copy)Abstract
Purpose of review Stroke is a leading cause of death and disability worldwide. Many strokes occur in patients with atrial fibrillation. Current guidelines recommend an antithrombotic regimen with warfarin to prevent thromboembolism in atrial fibrillation; however, a substantial number of patients are not eligible for this therapy. The exclusion of the left atrial appendage from circulation seems to be an alternative strategy for stroke prevention in atrial fibrillation. The review focuses on the different devices for stroke prevention in patients with atrial fibrillation. Recent findings Recently, two devices developed for percutaneous transcatheter occlusion of the left atrial appendage have been studied: the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) device and the WATCHMAN device. Safety and feasibility data are available for both devices. About 200 patients have received a PLAATO device. These patients were at high risk for thrombembolic stroke and were not candidates for oral anticoagulation therapy. The WATCHMAN device was implanted in 75 patients that were eligible for long-term anticoagulation therapy with a moderate risk for thrombembolic stroke due to nonvalvular atrial fibrillation. Summary For both devices, a reduction in the risk of stroke was documented, and device implantation was shown to be safe and feasible. Provided the ongoing trials show noninferiority to oral anticoagulation, another therapeutic option will become available to prevent ischemic strokes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | APPENDAGE TRANSCATHETER OCCLUSION; SPONTANEOUS ECHO CONTRAST; HIGH-RISK PATIENTS; CLINICAL IMPLICATIONS; EXPERIENCE; SYSTEM; THROMBOEMBOLISM; ANTICOAGULATION; COMPLICATIONS; PREVALENCE; atrial fibrillation; left atrial appendage; stroke; WATCHMAN device |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Nov 2020 07:06 |
| Last Modified: | 10 Nov 2020 07:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31404 |
Actions (login required)
 |
View Item |
