Gottfried, Eva and Kreutz, Marina and Mackensen, Andreas (2008) Tumor-induced modulation of dendritic cell function. CYTOKINE & GROWTH FACTOR REVIEWS, 19 (1). pp. 65-77. ISSN 1359-6101
Full text not available from this repository. (Request a copy)Abstract
Dendritic cells (DC) are specialized antigen presenting cells that acquire, process, and present tumor-associated antigens to T cells for the induction of antigen-specific tumor immune responses. DC have been shown to infiltrate many tumors but both, circulating and tumor-infiltrating DC from cancer patients, appear to be phenotypically and functionally defective. Several tumor-derived factors such as VEGF, IL6, IL-10, M-CSF, and STAT-3 have been shown to be responsible for systemic and local DC defects. Furthermore, tumor metabolites such as lactic acid may also critically contribute to DC dysfunction and tumor immune escape. The correction of abnormal DC function might be a requirement for successful vaccine approaches against cancer. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; COLONY-STIMULATING FACTOR; HUMAN-BREAST-CANCER; NEUROBLASTOMA-DERIVED GANGLIOSIDES; INDEPENDENT PROGNOSTIC-FACTOR; ANTIGEN-PRESENTING FUNCTION; EPIDERMAL LANGERHANS CELLS; HYPOXIA-INDUCIBLE FACTORS; STEADY-STATE CONDITIONS; CD4(+) T-CELLS; antigen presenting cells; dendritic cells; cancer vaccination; tumor immune escape; tumor-specific T cells |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 Dec 2020 10:45 |
| Last Modified: | 18 Dec 2020 10:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31405 |
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