Montesinos-Rongen, M. and Brunn, A. and Bentink, S. and Basso, K. and Lim, W. K. and Klapper, W. and Schaller, C. and Reifenberger, G. and Rubenstein, J. and Wiestler, O. D. and Spang, R. and Dalla-Favera, R. and Siebert, R. and Deckert, M. (2008) Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell. LEUKEMIA, 22 (2). pp. 400-405. ISSN 0887-6924, 1476-5551
Full text not available from this repository. (Request a copy)Abstract
To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEUKEMIA REVEALS; LOCALIZATION; DERIVATION; PCNSL; DLBCL; gene expression profiling |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Nov 2020 07:24 |
| Last Modified: | 10 Nov 2020 07:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31437 |
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