Garbe, Claus and Hauschild, Axel and Volkenandt, Matthias and Schadendorf, Dirk and Stolz, Wilhelm and Reinhold, Uwe and Kortmann, Rolf-Dieter and Kettelhack, Christoph and Frerich, Bernhard and Keilholz, Ulrich and Dummer, Reinhard and Sebastian, Guenther and Tilgenf, Wolfgang and Schuler, Gerold and Mackensen, Andreas and Kaufmann, Roland (2008) Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma. MELANOMA RESEARCH, 18 (1). pp. 61-67. ISSN 0960-8931, 1473-5636
Full text not available from this repository. (Request a copy)Abstract
The primary treatment of a melanoma is surgical excision. An excisional biopsy is preferred, and safety margins of 1 cm for tumor thickness up to 2 mm and 2 cm for higher tumor thickness should be applied either at primary excision or in a two-step procedure. When dealing with facial, acral or anogenital melanomas, micrographic control of the surgical margins may be preferable to allow reduced safety margins and conservation of tissue. The sentinel lymph node biopsy should be performed in patients whose primary melanoma is thicker than 1.0 mm and this operation should be performed in centers where both the operative and nuclear medicine teams are experienced. In clinically identified lymph node metastases, radical lymph node dissection is considered standard therapy. If distant metastases involve just one internal organ and operative removal is feasible, then surgery should be seen as therapy of choice. Radiation therapy for the primary treatment of melanoma is indicated only in those cases in which surgery is impossible or not reasonable. In regional lymph nodes, radiation therapy is usually recommended when excision is not complete (R1 resection) or if the nodes are inoperable. In distant metastases, radiation therapy is particularly indicated in bone metastases, brain metastases and soft tissue metastases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LYMPH-NODE BIOPSY; METASTATIC MALIGNANT-MELANOMA; TUMOR-NECROSIS-FACTOR; EARLY-STAGE MELANOMA; LONG-TERM SURVIVAL; RADIATION-THERAPY; CUTANEOUS MELANOMA; BRAIN METASTASES; PROGNOSTIC-FACTORS; STEREOTACTIC RADIOSURGERY; consensus-based; evidence; German; guidelines; interdisciplinary; melanoma; radiotherapy; surgical treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 Dec 2020 10:01 |
| Last Modified: | 18 Dec 2020 10:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31439 |
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