Kabelitz, Dieter and Geissler, Edward K. and Soria, Bernat and Schroeder, Insa S. and Faendrich, Fred and Chatenoud, Lucienne (2008) Toward cell-based therapy of type I diabetes. TRENDS IN IMMUNOLOGY, 29 (2). pp. 68-74. ISSN 1471-4906
Full text not available from this repository. (Request a copy)Abstract
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-producing pancreatic islet cells owing to the aggressive effector function of autoreactive T cells. In addition to lifetime supply of exogenous insulin, whole-pancreas or islet transplantation is presently the only alternative therapy for severely ill patients. Here, we discuss the current status of the development of cell-based therapies that are based on essentially two options, i.e. replacement of islet cells by islet-like cells derived from embryonic or adult stem cells, and re-establishment of immunological tolerance to islet self-antigens through regulatory T cells and/or tolerance-promoting monocyte-derived cells. A combination of both approaches will be required to turn cell-based therapy of T1D into clinical success.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; INSULIN-PRODUCING CELLS; EMBRYONIC STEM-CELLS; TRANSCRIPTION FACTOR FOXP3; EPIDERMAL-GROWTH-FACTOR; NOD MICE; TGF-BETA; COMBINATION THERAPY; AUTOIMMUNE-DISEASE; DENDRITIC CELLS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 Dec 2020 09:52 |
| Last Modified: | 18 Dec 2020 09:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31491 |
Actions (login required)
 |
View Item |
