Percutaneous Ablation of Hepatic Tumors Using Irreversible Electroporation: A Prospective Safety and Midterm Efficacy Study in 34 Patients

Niessen, Christoph and Beyer, Lukas P. and Pregler, Benedikt and Dellinger, Marco and Trabold, Benedikt and Schlitt, Hans J. and Jung, Ernst M. and Stroszczynski, Christian and Wiggermann, Philipp (2016) Percutaneous Ablation of Hepatic Tumors Using Irreversible Electroporation: A Prospective Safety and Midterm Efficacy Study in 34 Patients. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 27 (4). pp. 480-486. ISSN 1051-0443, 1535-7732

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Abstract

Purpose: To evaluate the safety and efficacy of percutaneous irreversible electroporation (IRE) of primary and secondary liver cancer unsuitable for resection or thermal ablation. Materials and Methods: In this prospective, single-center study, 65 malignant liver tumors (hepatocellular carcinoma; n = 33; cholangiocellular carcinoma, n = 5; colorectal cancer metastasis, n = 22; neuroendocrine cancer metastasis, n = 3; testicular cancer metastasis, n = 2) in 34 patients (27 men, 7 women; mean age, 59.4 y +/- 11.2) were treated. Local recurrence-free survival (LRFS) according to the Kaplan-Meier method was evaluated after a median follow-up of 13.9 months. Results: Median tumor diameter was 2.4 cm +/- 1.4 (range, 0.2-7.1 cm). Of 65 tumors, 12 (18.5%) required retreatment because of incomplete ablation (n = 3) or early local recurrence (n = 9). LRFS at 3, 6, and 12 months was 87.4%, 79.8%, and 74.8%. The median time to progressive disease according to modified Response Evaluation Criteria In Solid Tumors was 15.6 months. Overall complication rate was 27.5% with six major complications and eight minor complications. Major complications included diffuse intraperitonal bleeding (n = 1), partial thrombosis of the portal vein (n = 1), and liver abscesses (n = 4). Minor complications were liver hematomas (n = 6) and clinically inapparent pneumothoraces (n = 2). Conclusions: IRE showed promising results regarding therapeutic efficacy for the percutaneous treatment of liver tumors; however, significant concerns remain regarding its safety.

Item Type: Article
Uncontrolled Keywords: TISSUE ABLATION; CELLS ABLATION; LIVER; MODEL;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Anästhesiologie
Medicine > Lehrstuhl für Chirurgie
Medicine > Lehrstuhl für Strahlentherapie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 03 Apr 2019 08:55
Last Modified: 03 Apr 2019 08:55
URI: https://pred.uni-regensburg.de/id/eprint/3151

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