Hildebrandt, Gerhard C. and Granell, Miguell and Urbano-Lspizua, Alvaro and Wolff, Daniel and Hertenstein, Bernd and Greinix, Hildegard T. and Brenmoehl, Julia and Schulz, Christian and Dickinson, Anne M. and Hahn, Joachim and Rogler, Gerhard and Andreesen, Reinhard and Holler, Ennst (2008) Recipient NOD2/CARD15 variants: A novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14 (1). pp. 67-74. ISSN 1083-8791,
Full text not available from this repository. (Request a copy)Abstract
Bronchiolitis obliterans (BO) is a serious complication after allogeneic stem cell transplantation. We hypothesized that single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene (= NOD2/CARD15 variants) contribute to changes in host defense and subsequent alloreaction, leading to BO. We analyzed 427 donor-recipient pairs for the association of NOD2/CARD15 variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) with BO occurrence. Overall, 11 patients (2.6%) developed BO. The cumulative incidence of BO rose from 1.3 % in donor-recipient pairs without mutation to 18.7% in pairs with donor or recipient NOD2/CARD15 variants (P <.001). Recipient NOD2/CARD15 variants alone led to BO in 22.3% (P <.001), whereas donor variants alone associated with BO in 13.2% (P =.04). Multivariate analysis proved recipient but not donor NOD2/CARD15 variants to be a novel independent risk factor for BO development, and NOD2/CARD15 typing may help identify patients at increased risk for BO. (c) 2008 American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; NONINFECTIOUS PULMONARY COMPLICATIONS; INTESTINAL EPITHELIAL-CELLS; AIR-FLOW OBSTRUCTION; CROHNS-DISEASE; ANTIMICROBIAL PEPTIDES; LUNG TRANSPLANTATION; CARD15 MUTATIONS; AIRWAYS DISEASE; bronchiolitis obliterans; chronic GVHD; NOD2; stem cell transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Nov 2020 09:17 |
| Last Modified: | 11 Nov 2020 09:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31552 |
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