Huesemann, Yves and Geigl, Jochen B. and Schubert, Falk and Musiani, Piero and Meyer, Manfred and Burghart, Elke and Forni, Guido and Eils, Roland and Fehm, Tanja and Riethmueller, Gert and Klein, Christoph A. (2008) Systemic spread is an early step in breast cancer. CANCER CELL, 13 (1). pp. 58-68. ISSN 1535-6108,
Full text not available from this repository. (Request a copy)Abstract
It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2 transgenic glands displayed disseminated tumor cells and micrometastasis in bone marrow and lungs. The number of disseminated cancer cells and their karyotypic abnormalities were similar for small and large tumors in patients and mouse models. When activated by bone marrow transplantation into wild-type recipients, 80 early-disseminated cancer cells sufficed to induce lethal carcinosis. Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CYTOKERATIN-POSITIVE CELLS; BONE-MARROW; TRANSGENIC MICE; MAMMARY-CARCINOMA; METASTASIS; PROGRESSION; EXPRESSION; REVEALS; MODEL; TUMOR; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Nov 2020 09:44 |
| Last Modified: | 11 Nov 2020 09:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31568 |
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