Zietz, Sabrina and Happle, Rudolf and Hohenleutner, Ulrich and Landthaler, Michael (2008) The venous nevus: A distinct vascular malformation suggesting mosaicism. DERMATOLOGY, 216 (1). pp. 31-36. ISSN 1018-8665,
Full text not available from this repository. (Request a copy)Abstract
Background: Venous malformations are common vascular anomalies which only occur sporadically. Objective: We present a series of 25 patients with extratruncular venous malformations of the skin or the neighboring mucosa that are arranged in a segmental pattern. Results: All lesions were sporadic and mostly unilateral. According to the extent of the vascular malformation, two subgroups were defined: large- to medium- sized and small localized lesions ('acrofacial distribution'). In large- or medium- sized lesions, we noted a strict midline separation of the disorder. Thus, we assume that this segmental arrangement reflects genetic mosaicism. Conclusions: This type of venous malformation originates from a postzygotic mutation that occurs at an early developmental stage. Hence, the type of vascular disorder present in our 25 patients seems to fulfil each criterion of the term 'nevus'. This vascular nevus should be distinguished from other forms of venous malformations such as the varicose veins associated with the Klippel-Trenaunay syndrome, the dermal nodules of the blue rubber bleb nevus syndrome and the vascular skin lesions of the Maffucci syndrome. Thus, we propose the new term 'venous nevus' or 'nevus venosus'. Copyright (C) 2008 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TYROSINE KINASE TIE2; venous malformation; mosaicism; postzygotic mutations; vascular nevi; nevus venosus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Nov 2020 12:40 |
| Last Modified: | 11 Nov 2020 12:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31617 |
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