Podar, Mircea and Anderson, Iain and Makarova, Kira S. and Elkins, James G. and Ivanova, Natalia and Wall, Mark A. and Lykidis, Athanasios and Mavromatis, Kostantinos and Sun, Hui and Hudson, Matthew E. and Chen, Wenqiong and Deciu, Cosmin and Hutchison, Don and Eads, Jonathan R. and Anderson, Abraham and Fernandes, Fillipe and Szeto, Ernest and Lapidus, Alla and Kyrpides, Nikos C. and Saier, Milton H. and Richardson, Paul M. and Rachel, Reinhard and Huber, Harald and Eisen, Jonathan A. and Koonin, Eugene V. and Keller, Martin and Stetter, Karl O. (2008) A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. GENOME BIOLOGY, 9 (11): R158. ISSN 1474-760X,
Full text not available from this repository. (Request a copy)Abstract
Background: The relationship between the hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans is the only known example of a specific association between two species of Archaea. Little is known about the mechanisms that enable this relationship. Results: We sequenced the complete genome of I. hospitalis and found it to be the smallest among independent, free-living organisms. A comparative genomic reconstruction suggests that the I. hospitalis lineage has lost most of the genes associated with a heterotrophic metabolism that is characteristic of most of the Crenarchaeota. A streamlined genome is also suggested by a low frequency of paralogs and fragmentation of many operons. However, this process appears to be partially balanced by lateral gene transfer from archaeal and bacterial sources. Conclusions: A combination of genomic and cellular features suggests highly efficient adaptation to the low energy yield of sulfur-hydrogen respiration and efficient inorganic carbon and nitrogen assimilation. Evidence of lateral gene exchange between N. equitans and I. hospitalis indicates that the relationship has impacted both genomes. This association is the simplest symbiotic system known to date and a unique model for studying mechanisms of interspecific relationships at the genomic and metabolic levels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HORIZONTAL GENE-TRANSFER; PYRUVATE-FERREDOXIN OXIDOREDUCTASE; HYDROGENOBACTER-THERMOPHILUS TK-6; HYPERTHERMOPHILIC ARCHAEON; NITRATE REDUCTION; OUTER-MEMBRANE; TRANSFER-RNAS; SP-NOV; EVOLUTION; DOMAIN; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie (Archaeenzentrum) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Nov 2020 11:08 |
| Last Modified: | 13 Nov 2020 11:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31647 |
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